The Partners have extensive experience structuring early stage technology and life sciences investments in multiple disciplines. Our portfolio company markets include products and services in fields as diverse as telecommunications network management, Internet commerce, online video indexing, analog semiconductor design, public safety information systems, radiology information systems, anticancer drug testing, and mass data storage.
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Be Here is the leading global provider of software and hardware products used to capture and deliver panoramic and wide-angle navigable video and still pictures across multiple industries and applications. Its patented, solid-state, single-camera imaging technology provides a seamless up to 360-degree image that provides videoconference participants and security monitors a live or recorded user controlled "be here" experience that is unique within the industry.
Cvent is the leading applications service provider of web-based enterprise software for the meeting and event planning industry. The company develops and markets a powerful suite of web-based event planning, marketing, and data analysis tools to alleviate the three major pain points of traditional event planning that includes invitation registration inefficiencies, impersonal mass marketing, and under-utilization of valuable member data. In addition to its proprietary event and data engine, the company's technology is based on the Microsoft Distributed interNet Applications (DNA) architecture and MicroStrategy's Broadcaster platform.
CyOptics is a full-line supplier of high-speed optical chips and components for broadband access, metro, and long-haul communications systems. The company develops active indium phosphide laser and detector components that are manufactured on a highly flexible, ?nano-tech? capable robotic assembly process that delivers high uniformity and low cost. These next-generation optical engines are five times smaller than the current industry standard components, in order to maximize the functional density/price. It has chip fabrication operations in Lehigh Valley, PA and automated packaging and testing operations in Matamoros, Mexico.
Inspired Technologies develops respiratory products that help patients live longer, healthier lives. The company aligns the goals of patients, clinicians, providers, and payers—all the while focusing on improving patient outcomes and quality of life. The VIAspire Personal Oxygen System gives patients the freedom and confidence to live active lives—with no need for oxygen deliveries. The system creates a daily supply of liquid oxygen in the home, and lightweight patient portables can be filled in minutes. SmartDose technology increases oxygen delivery when the patient needs it most, encouraging activity and independence.
LogicLibrary, a leading innovator in software asset management for application assembly, provides software and services that help enterprise application development teams build a foundation for Web services by efficiently and effectively creating custom solutions that map to their company's ever-changing business needs. LogicLibrary's patent-pending technology incorporates asset mapping to strategic business process models and enables IT teams to capture, leverage and manage pre-built solution assembly assets for the most rapid and cost-effective assembly of today's enterprise business applications.
Metabolex is a privately held pharmaceutical company dedicated to the discovery and development of drugs to treat diabetes and related metabolic disorders. Its lead compound, MBX-102, is a novel insulin sensitizer in Phase II-III clinical development. The company has built a portfolio of other potential diabetes therapeutics and is engaged in a number of target discovery programs with Abbott, Pfizer, and Yamanouchi Pharmaceuticals.
NuPathe, Inc. is a specialty pharmaceutical company developing innovative therapies for the treatment of neurological and psychiatric disorders including migraine, Parkinson’s disease, and schizophrenia. Its lead product, NP101, uses SmartRelief, the company’s novel, transdermal patch technology, to deliver sumatriptan to treat migraine. Pending regulatory review and approval, NP101 would be the first ever migraine treatment based on a transdermal patch delivery.
Plextronics, Inc. is a leading innovator of technology for printed electronics. The printed electronics market comprises next-generation light, power and circuitry products including flexible displays, plastic solar cells and organic RFID tags. With a company vision of enabling 15 billion printed electronics devices by 2015, Plextronics is creating technology capable of commercial-scale performance and manufacturability. The company's device design, process technology, and Plexcore branded inks enable the formation of active electrical layers -- the key drivers of printed electronics.
Precision Therapeutics is a personalized cancer management services company. Its patented ChemoFX Assay is used to successfully grow human tumor-derived cells in culture and then test these cells for drug sensitivity and/or resistance. The results provide medical and surgical oncologists with patient-specific tumor information that may provide additional insight into optimal therapy options when determining the appropriate course of treatment for an individual patient. The company also provides services to the biopharmaceutical industry to improve the selection of effective drugs and responsive tumors to decrease drug development costs significantly.
Protez Pharmaceuticals discovers and develops novel antibiotics for difficult-to-treat infections. Its focus is on highly differentiated intravenous and oral small molecule antibiotics to address increasing bacterial resistance and chronic or recurrent infections. Protez intends to acquire, develop, and commercialize additional antibiotic product opportunities to which it can add significant value by leveraging its core technologies and drug development expertise.
PTC Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of small-molecule drugs targeting post-transcriptional control mechanisms. Post-transcriptional control processes are the sequence of events in the cell that ultimately regulate the rate and timing of all protein production. PTC?s compounds alter these processes by selectively modulating how RNA is used to produce proteins. By applying this approach, PTC has advanced its drug discovery programs rapidly from targets to preclinical and clinical drug candidates, building a robust pipeline across genetic disorders, oncology, and infectious diseases.
Renal Solutions provides revolutionary products and services for renal failure patients that improve quality of life and aide in the reduction of the total cost of treatment. It is the only provider of dialysis products and services utilizing sorbent-based technology to regenerate dialysate. Its lead product, The Allient? Sorbent Hemodialysis System, is based on a patented sorbent hemodialysis regeneration system that has been developed by the company. The Allient? System is a self-contained hemodialysis unit utilizing sorbent technology and an innovative and proprietary blood movement system, which together provide for significantly improved safety and ease of use features. The Allient? System addresses many of the limitations of current dialysis products and methods. The Allient? System and the associated sorbent series of cartridges have recently been evaluated by the FDA have been cleared for sale.

Previous Investments
[NASDAQ: ARBA]
Ariba offers a powerful suite of solutions to help companies manage spending so that expenses fall faster than revenues in down times, and grow more slowly than revenues in up times. Ariba remains at the forefront of the Internet evolution, providing easy-to-implement, robust online commerce solutions for proven cost savings and return on investment. Ariba now leads the Enterprise Spend Management (ESM) market, a new class of solutions that focus on delivering a closed loop of control and leverage over a company's spend, including assessing spending activities, conducting effective sourcing and capturing and reconciling spend enterprise-wide. The company acquired Birchmere portfolio company FreeMarkets, Inc. [NASDAQ: FMKT] in July 2004.
[NYSE: CDN]
Cadence is the world?s largest supplier of electronic design technologies and engineering services. Its new generation solutions are used to accelerate and manage the design of semiconductors, computer systems, networking and telecommunications equipment, consumer electronics, and a variety of other electronics-based product. The company has sales offices, design centers, and research facilities around the world. Cadence acquired Birchmere portfolio company NeoLinear Inc. in April 2004.
[NASDAQ: CCBL]
C-COR is a top-tier global provider of optical packet and digital video transport communications products, end-to-end fiber-to-the-premise systems, comprehensive OSS solutions, and high-end technical outsourced field services which all supporting cost-effective delivery of voice, video, and high-speed data over advanced broadband networks. In September 2004 C-COR acquired Birchmere portfolio company Optinel Systems, whose products provide Multiple Systems Operators (MSOs) with the ability to build low-latency fiber-optic networks capable that easily integrates with existing hardware and enables the simultaneous transmission of video, data, and voice traffic in native formats over long distances.
[AMEX: YMI]
EXIMIAS Pharmaceutical Corporation is an emerging specialty pharmaceutical company focusing on the acquisition, development and commercialization of unique oncology and infectious disease products. The company’s lead compounds are nimotuzumab (an anti-EGFr humanized monoclonal antibody) and AeroLEF (a unique inhaled delivery of free and liposome encapsulated fentanyl to treat acute pain including cancer pain). YM Biosciences acquired Eximias Pharmaceuticals in May 2006.

[NASDAQ: ICOR]
Formerly Paradigm Genetics, Icoria is a biotechnology company that uses gene expression, metabolomics and tissue feature profiling to identify biomarkers to accelerate drug discovery. In March 2004, Paradigm Genetics acquired portfolio company TissueInformatics (TII), which develops and applies automated pathology software for the quantitative analysis of tissue changes in drug discovery, disease assessment, toxicology, and tissue engineering.
Interscope provides practical tools that improve pathologists' work environment, increase efficiency, and save valuable staff time. Its products automatically capture high resolution, full color images of entire microscope slides - rapidly integrating multi-resolution slide images with clinical information into a flexible software environment.
[OTCBB: KNVS]
Following ServiceWare's merger with Kanisa in 2005, the company rebranded itself Knova Software, Inc. Knova Software is a leading provider of service resolution management applications that reduce service costs, increase revenues through improved customer satisfaction. Built on a next-generation search and knowledge management platform, Knova?s suite of knowledge-empowered customer service applications automate the resolution process across multiple channels including contact centers, help desks, email, and self-service sites. ServiceWare completed its public offering in August 2000.
Lightningcast is the leading advertising services provider for streaming media, enabling streaming media publishers to insert targeted, audited advertising into existing content using unique, patent-applied technology. Content providers can thus specifically target desired streaming media consumers. The company was acquired by AOL in May 2006.
ParaData
Develops records management software for public safety organizations. Enables police, fire, and emergency services to efficiently dispatch their resources, electronically collect all relevant data at the incident site, and automatically search for relevant information such as outstanding warrants in databases at the city, county, state, and federal levels. ParaData was sold privately to Paradigm4 in 1998.
[NYSE: PQE]
ProQuest Company is a leading publisher of information solutions for the education, automotive, and power equipment markets. With more than 2,500 employees and $400 million in revenue, ProQuest gives its customers access to a body of information and images that is unmatched in breadth and depth. In December 2005, ProQuest acquired the legacy Order and Catalog business from Birchmere portfolio company Entigo Corporation.
[NASDAQ: SOFO]
Sonic Foundry is a provider of rich media communications technology for the enterprise. The company's high-performance Webcasting and Web presentation solutions are trusted by Fortune 500 companies, education institutions, and government agencies for a variety of critical communication needs. Sonic Foundry acquired Birchmere portfolio company MediaSite in September 2001.
[NYSE: STK]
StorageTek is a $2 billion global company that enables businesses, through its information lifecycle management strategy, to align the cost of storage with the value of information. The company's innovative storage solutions manage the complexity and growth of information, lower costs, improve efficiency and protect investments. StorageTek acquired Birchmere portfolio company Safeguard Interactive in July 1999.
Established in 1986, Syndesis is one of the industry?s premier OSS software developers. Their products empower the world?s largest telecommunications companies to provide new network experiences for their customers by enabling rapid and reliable delivery of profitable next generation data services. Syndesis is the vendor of choice in deployments at more than 20 major service providers worldwide. Syndesis acquired Birchmere portfolio company CoManage in August 2005. CoManage is a leader in network-driven data integrity management systems that help carriers improve the accuracy of data in their existing operations support systems for more profitable service delivery.
Webmedx is a healthcare applications solution provider focused on the production and access of clinical information. Webmedx applications provide workflow solutions to the complex and costly process of report production, patient information access and revenue capture management.

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